BACKGROUND: Folate and vitamin Bare involved in metabolic reactions for combating oxidative stress. We measured erythrocyte folate and plasma vitamin Band compared these with blood antioxidants – erythrocyte glutathione (GSH), glutathione peroxidase (GPx), superoxide dismutase (SOD), and plasma vitamin C – and marker of lipid peroxidation, thiobarbituric acid reactive substance (TBARS), in chronic pancreatitis (CP) patients.

METHODS: One hundred and seventy-five CP patients (91 tropical, 84 alcoholic) and 113 healthy controls were recruited. Erythrocyte folate and plasma vitamin Bwere measured using microbiological assay, and antioxidant levels and erythrocyte TBARS by spectrophotometry.

RESULTS: Erythrocyte folate and plasma vitamin Bwere significantly lower in CP patients than controls (225.4± 9.13 vs. 380.38 ± 17.29 nmol/L, p

CONCLUSION: Low folate and vitamin Blevels were associated with increased oxidative stress in CP patients.

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